Prognosis for De Grouchy Syndrome: The prognosis varies depending on the type and severity of symptoms that develop - some patients have a reasonable prognosis whereas others suffer severe handicap. De Grouchy syndroom The deletion involves the distal section of 18q and typically extends to the tip of the long arm of chromosome 18. De Grouchy syndrome manifests clinically as mental retardation. Ten to fifteen percent of people with 18p- have holoprosencephaly, suggesting that other genetic and environmental facts play a role in the etiology of holoprosencephaly in these individuals. Current research is focused on establishing genotype-phenotype correlations to enable predictive genotyping. 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